Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems
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منابع مشابه
Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems.
Although nociceptin/orphanin FQ (N/OFQ) influences dopamine (DA) neuronal activity, it is not known whether N/OFQ acts directly on DA neurons, indirectly by means of local circuitry, or both. We used two parallel approaches, dual in situ hybridization (ISH) and neurotoxic lesions of DA neurons by using 6-hydroxydopamine (6-OHDA), to ascertain whether N/OFQ and the N/OFQ receptor (NOP) mRNA are ...
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The recently discovered neuropeptide orphanin FQ (OFQ), and its opioid receptor-like (ORL1) receptor, exhibit structural features suggestive of the micro, kappa, and delta opioid systems. The anatomic distribution of OFQ immunoreactivity and mRNA expression has been reported recently. In the present analysis, we compare the distribution of orphanin receptor mRNA expression with that of orphanin...
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ژورنال
عنوان ژورنال: The Journal of Comparative Neurology
سال: 2002
ISSN: 0021-9967,1096-9861
DOI: 10.1002/cne.10154